Sample collection was performed by Gokhan Mutlu lab at University of Chicago. 5 month mice were CO2 euthanized. Liver and blood cells from individual mouse were isolated for subsequent DNA and RNA extractions according to the standard operation procedure described by the TaRGET II consortium. Please refer to TaRGET II data portal (https://data.targetepigenomics.org) for details. ATAC-seq and mRNA-seq experiments were performed by Gokhan Mutlu lab at University of Chicago. mRNA and nuclei from 5 month mice liver and blood were isolated for subsequent ATAC-seq and mRNA-seq library preparations according to the operation procedure described by the TaRGET II consortium. Please refer to TaRGET II data portal (https://data.targetepigenomics.org) for details.