ChIP was performed with SimpleChIP Plus Enzymatic Chromatin IP Kit (Cell Signaling Tech. #9005) following the standard protocol. About 4 million cells were used for each ChIP experiment, with two antibodies of LSD1 (Cell Signaling Tech. #2184, clone C69G12; and Abcam, ab17721). Massively parallel sequencing was performed with the Illumina HiSeq4000 according to the manufacturer's protocol, and paired-end 150 bp-length reads were produced.