For ChIP-Seq samples: phenol-chloroform extraction For RNA-Seq samples: RNeasy kit (Qiagen) following the on-column DNase digestion protocol. For ChIP-Seq samples: Libraries were prepared using the NEXTflex ChIP-Seq kit (Bio Scientific) following the “No size-selection cleanup” protocol. For RNA-Seq samples: Total RNA was subjected to mRNA 3ʹ end sequencing library preparation (QuantSeq, Lexogen).