Cells were double-crosslinked and nuclei were isolated. Lysates were clarified from sonicated nuclei and incubated with the corresponded antibody Antibody-DNA complexes were decrosslinked and DNA was isolated by SPRI beads. Libraries were prepared as previously described (Blecher-Gonen et al., 2013). Libraries were sequenced on the an Illumina Nextseq500 platform following the manufacturer's protocols.