ATAC-seq: ATAC-seq library preparation was done as described in (Buenrostro et al. 2013) using Transposomes from Nextera DNA library preparation kit (Illumina, San Diego, CA) and custom primers. Libraries were run single read on the Illumina NexSeq500. RNA-seq: Total RNA was isolated by use of RNeasy Micro Kit (Qiagen, Hilden, Germany) according to manufacturer's recommendations. RNA-seq libraries were constructed using NuGEN's Ovation Ultralow Library systems (NuGEN Technologies, San Carlos, CA) and were subsequently subjected to 76 cycles of NextSeq500 sequencing (Illumina, San Diego, CA).