Total genomic DNA for all samples (except input) were extracted following immunoprecipitation using the Pierce Magnetic ChIP Kit (Thermo Scientific, Cat# 26157) following the manufacturer's instructions. Antibodies used were specific for either H3K27ac or H3K27me3 (Active Motif). Genomic DNA for input samples were prepared using the same protocol but without immunoprecipitation. Libraries were prepared according to NEB's instructions accompanying the NEBNext DNA Ultra II kit (catalog # E7645S). Libraries were sequenced on the NextSeq 500 following the manufacturer's protocols.