For RNA-seq, total RNA were extracted with RNeasy Plus Mini kit (Qiagen). For ATAC-seq and ChIP-seq home-made protocols were used (see Materials and Methods) ChIP-seq : MicroPlex Library Preparation Kit (Diagenode) ; ATAC-seq : Nextera DNA Library Prep Kit (Illumina) ; RNA-seq in GMPs : TruSeq Stranded Total RNA with Ribo Zero Gold kit (Illumina) ; RNA-seq in 416b : SMART-Seq v3 Ultra Low Input RNA kit for (Clontech)