DNA was extracted using tale lysis buffer (50mM Tris-Cl pH8.5; 5mM EDTA; 200mM Nacl; 0.25% SDS) and 1 µg/ml Proteinase K for 1 hr. The mixture was purified with phenol/chloroform extraction and precipitated with isopropanol. Paired-end libraries were prepared and sequenced in 100bp reads run according to Illumina instructions.