RNA was extracted with Trizol; ChIP DNA was extracted with Qiagen Gel Extraction kit; ATAC-seq DNA was extracted with Qiagen MinElute PCR purification kit RNA-seq libraries were prepared with TruSeq Stranded mRNA Library Prep Kit (Illumina, RS-122-2101); ChIP DNA libraries were constructed with ThruPLEX® DNA-seq Kit (Rubicon Genomics), ATAC-seq libraries were prepared with Illumina Nextera DNA Library Prep Kit (15028212).