Native ChIP was performed on 1x10^7 cells. Cell pellets were lysed and chromatin was digested using MNase (Sigma N5386) at 37°C with an ideal fragmentation between 200 and 1000bp. The reaction was stopped using 5mM EDTA. HA antibody was collected with dynabeads (Invitrogen, 112.03D, 112.01D) from 12AC5 hybridoma supernatants and then incubated with the lysates overnight at 4oC. After several washes, the samples were treated with proteinase K and RNAse. DNA was purified using the PCR-purification Qiagen kit (28104). Libraries were prepped using the NEB DNA Ultra kit, with bead bases size selection for an insert ~200bp and sequenced on the Illumina NextSeq 500, v2 chemistry