MNase digested chromatin was allowed to bind to antibodies for 2-4 hours. Paramagnetic protein G dynabeads were added for an additional hour and the beads were extensively washed. Bound chromatin was ligated to barcoded DNA adapters, and chromatin was reverse cross linked and pooled. Barcoded chromatin was amplified with Illumina NGS - compatible primers and DNA libraries were paired end sequenced by Illumina NextSeq 500.