RNA: Trizol followed by depletion of ribosomal RNA using the ribominus V2 kit (Life technologies) and size selection using the mirVana separation kit (Life technologies), DNA: Phenol-Chloroform Libraries were prepared according to NEB instructions accompanying the following kits: ChIP/CHART-sequencing: NEBNext ChIP-seq library Prep Master MIX set, Short-RNA-sequencing:NEBnext small RNA library construction kit (NEB), RNA-sequencing: NEBNext Ultra directional RNA library kit (NEB)