For ChIP, cells were crosslinked in 1% Formaldehyde at room temperature at for 10 min before harvest. Chromatin was sheared to 300-500 bp and DNA-protein complexes were isolated with antibody. Precipitates were digested with RNaseA and Proteinase K and then Phenol-Chloroform purified. For ChIP-Seq, DNA was quantified using the Qubit® dsDNA HS Assay Kit (Invitrogen). 1-5 ng DNA from ChIP experiments were used for library preparation using the Illumina ChIP-Seq sample prep kit (IP-102-1001) and multiplexing oligonucelotide kit (PE-400-1001). For DNA purification steps, DNA SPRI bead (Beckman) cleanup was performed. The quality of the DNA libraries was assessed using a high sensitivity Bioanalyzer Chip (Agilent). Libraries were used for cluster generation and sequencing using HiSeq 2000 (Illumina) with 50 bp read length.