Rabbit polyclonal raised against epitope mapping at the C-terminus of NF-E2 p18 of mouse origin; recommended for detection of NF-E2 p18 (MafK) of mouse, rat and human origin. Antibody Target: MafK
NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG, or MafK) and p45. Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP)proteins. Since they lack a putative transactivation domain, small Mafs behave as transcriptional repressors when they dimerize among themselves. They serve as transcriptional activators by dimerizing with other (usually larger) bZip proteins and recruiting them to specific DNA-binding sites.