Cells were cross-linked in 1% formaldehyde, lysed and then sheared chromatin was immunoprecipitated with antibodies targeting histone marks [H3K36me2 (Abcam, ab9049), H3K27me3 (Abcam, ab6002), H3K27ac (Abcam, ab4729) and H3K9ac (Millipore, 06-942)]. A small aliquot was set aside prior to immunoprecipitation as input DNA. Quality control was performed using an Agilent Technologies 2100 Bioanalyzer prior to library preparation. KAPA HyperPrep Kit was used for library construction