Eight million WT and KO BEAS-2B cells were fixed and subjected to immunoprecipitation using ChIP-grade antibodies against H3K4me3 (Active Motif Cat# 39159), H3K9me3 (Active Motif Cat# 39161), H3K27me3 (Active Motif cat #39155) and H3R8me2a (Active Motif cat #39651). ChIP and input/control DNA were prepared for sequencing using Illumina NextSeq 500. Libraries were generated using Next Gen DNA library kit (active motif #53216)