ChIP-Seq: After sonicating nuclei, histone-DNA complexes were isolated with antibody. ChIP-Seq: Libraries were constructed according to Illumina's NEXTflexTM ChIP-Seq Kit (Catalog # 5143-02). RNA-Seq: Total RNA was extracted from each cell line using TRIzol reagent. RNA-Seq: 1 ug of total RNA was used to prepare libraries according to Illumina TruSeq RNA Sample Prep Kit (Part # 15027084).