Chromatin lysates were clarified from sonicated cells and histone-DNA complexes were isolated with respective antibodies. Sequencing library preparation and reactions were conducted at City of Hope's Integrative Genomics Core. ChIP-seq libraries were made using Illumina Tru-Seq library preparation kit and multiplexing barcodes compatible with Illumina HiSeq 2500 technology. RMA-seq libraries were prepared using Kapa Hyper Prep Kit (Kapa Biosystems)