Cross-linked chromatin was sonicated to achieve an average fragment size of 500 bp. 150 ug of Chromatin and 5 ug of anti-Tead2 antibody were used for ChIP. The ChIP libraries were prepared with the Illumina ChIP-Seq DNA Sample Prep Kit (Cat# IP-102-1001) according to Illumina’s instructions and sequenced on the Genome Analyzer 2 following the manufacturer’s protocols.