Lysates were clarified from sonicated nuclei and ERF-DNA complexes were isolated with antibody. Fragmented immunoprecipitated DNA samples, in the range <0.1 to 5ng, were processed with "NEBNext Ultra II DNA Library Prep Kit for Illumina" from New England BioLabs (catalog # E7645). Briefly, samples went through subsequent enzymatic treatments of end-repair, dA-tailing, and ligation to adapters. Adapter-ligated libraries were completed by limited-cycle PCR and extracted with a [single] double-sided SPRI size selection. Median fragment sizes were 600 and 480 bp for samples "rep1" and "rep2", respectively, from which 120 bp correspond to adaptor sequences. Libraries were applied to an Illumina flow cell for cluster generation and sequenced on an Illumina HiSeq2500 instrument by following manufacturer's protocols.