For RNA-seq, cells were lysed with Trizol (Thermo Fisher Scientiic). After phase separation, RNA was purified by PureLink RNA Mini Kit (Thermo Fisher Scientific). For ChIP-Seq, protein-DNA complex were crosslinked by formaldehyde, sonicated, immunoprecipitated and extracted after reverse-crosslinking (see details in 2016 PNAS 113, E6072) Fisher Scientific) For RNA-seq, use TruSeq stranded mRNA preparation kit (Illumina). For ChIP-seq, use ThruPLEX DNA-seq Kit (RUBICON GENOMICS).