Bone marrow (BM) cells were isolated from Gfi1bfl/fl MxCretg NUP98/HOXD13tg and Gfi1bfl/fl MxCrewt Nup98/HOXD13 mice. BM cells were homogenised and ery lysis was performed. 1x10^7 cells were fixed with 1% formaldehyde and sonicated for 20 min. Histone-DNA antibody were isolated with antibody Libraries were prepared using the NEBNext® UltraTM DNA Library Prep Kit for Illumina®. Samples were pooled after quality check.