the spleens were isolated from NUP98/HOXD13 mice carrying either the human GFI136S or the human GFI136N cDNA. The spleens were homogenised and ery lysis was performed. 3x10^7 cells were fixed with 0.4% formaldehyde and sonicated for 20 min. Histone-DNA antibody were isolated with antibody Libraries were prepared using the NEBNext® UltraTM DNA Library Prep Kit for Illumina®. Samples were pooled after quality check.