ZZZ3 contains one ZZ-type zinc finger domain. ZZ type finger domains are named because of their ability to bind two zinc ions. These domains contain 4-6 Cys residues that participate in zinc binding (plus additional Ser/His residues), including a Cys-X2-Cys motif found in other zinc finger domains. These zinc fingers are thought to be involved in protein-protein interactions -they are most likely involved in ligand binding or molecular scaffolding. The structure of the ZZ domain shows that it belongs to the family of cross-brace zinc finger motifs that include the PHD, RING, and FYVE domains.
Lazlo Tora, Institut de G?n?tique et de Biologie Mol?culaire et Cellulaire