Immunoprecipitation was carried out using antibodies against EpCAM and Lef-1 on SX-8G-Star Compact Automated System following the manufacturer’s instructions. Pull-down products were purified and checked for size distribution for quality control by 2100 Bioanalyzer. Library construction and sequencing were performed in the Genome Sequencing Facility in University of Texas Health Science Center at San Antonio by HiSeq 2000 sequencing system under the guidelines.