Lysates were clarified from sonicated nuclei and protein-DNA complexes were isolated with the respective histone antibodies. Sequencing libraries were generated for the H3K27ac, H3K4me1, and H3K4me3 samples (samples were divided in half, and two libraries made for each using different multiplexed adaptors) Clustering and 50-cycle single end sequencing were performed on the Illumina Illumina HiSeq 2000 Genome Analyzer. Libraries were sequenced on the Illumina Illumina HiSeq 2000, with 50bp single end sequencing